Research Interests

The Brik Lab operates at the intersection of organic chemistry, biology, and medicine. Our research centers on creating innovative chemical and semi-synthetic techniques to produce proteins with distinctive modifications. By achieving precise atomic-level control over protein structures, we strive to understand complex biological signalling pathways, especially the “ubiquitin code,” and develop next-generation therapeutics for cancer and other diseases.

Innovation in Chemical Protein Synthesis Using Transition Metal Catalysis
The core of our research involves developing advanced chemical and semi-synthetic methods to assemble large, complex proteins with atomic accuracy...

Deciphering the Ubiquitin Code and Ubiquitin-like Modifiers (Ubls)
We aim to decode the complex signalling language of the Ubiquitin-Proteasome System (UPS) and related modifiers such as SUMO, ISG15, and URM1...

Discovery of Macrocyclic Peptides and Targeted Therapeutics
By integrating chemical protein synthesis with the RaPID (Random Non-standard Peptides Integrated Discovery) system, we discover de novo macrocyclic peptides that act as high-affinity modulators…

Protein Chemistry in Live Cells: Delivery, Imaging, and Proteostasis
We are extending synthetic protein chemistry into the live-cell environment to study protein function in real-time...