Professor Ashraf Brik completed his undergraduate studies in Chemistry in 1996 at the Ben-Gurion University of the Negev. Brik attended the Technion-Israel Institute of Technology for his M.Sc. degree and became interested in organic synthesis of natural products. Under the guidance of Dr. Nizar Haddad, Brik worked on the total chemical synthesis of Borrelidin, a natural antibiotic macrolide. In 1998, he moved to The Scripps Research Institute (TSRI) where he worked under the guidance of Professor Ehud Keinan and Professor Philip E. Dawson on a joint program between the Technion and TSRI, in the area of chemical synthesis of proteins. He used the developed chemical tools to study the mechanism of 4-Oxalocrotonate tautomerase and alter its activity from tautomerase to decarboxylase through chemical point mutations. He completed his Ph.D. in 2001, thereafter started his postdoctoral position with Professor Chi-Huey Wong (TSRI). During this time, Brik developed methods to facilitate the discovery of inhibitors against various enzymes. Specifically, Brik developed an approach named microtiter plate-based chemistry and
in situ screening for the discovery of potent inhibitors against HIV protease, beta-aryl sulfotransferase, and SARS human corona virus protease. In 2004, he was promoted to a Sr. Research Associate in the Wong Laboratory and became involved in the synthesis of glycopeptides and glycoproteins applying his knowledge and skills in protein chemistry. In 2007, Brik returned to his Alma Mater as an Assistant Professor at the Chemistry Department in BGU and was promoted to an Associate Professor in 2011 and to a Full Professor in 2012. In 2015, Brik moved to the Schulich Faculty of Chemistry at Technion where he where he holds the Jordan and Irene Tark Academic Chair. His research involves the development of novel chemistries and approaches for the chemical synthesis and semisynthesis of posttranslationally modified proteins (e.g. ubiquitinated, glycosylated and phosphorylated proteins) for biochemical, biophysical and biological studies. His group is also interested in the design and synthesis of modulators based on small molecules, peptides and peptidomimetics for enzymes which are involved in various diseases.
Born on June 29, 1973, Israel.
Ph.D. Technion-Israel Institute of Technology, Department of Chemistry, Haifa, Israel. Advisor: Professor Ehud Keinan, jointly with The Scripps Research Institute, La Jolla, California. Advisor: Professor Phillip Dawson.
M.Sc. Technion-Israel Institute of Technology, Department of Chemistry, Haifa, Israel.
B.Sc. Ben-Gurion University of the Negev, Department of Chemistry, Beer Sheva, Israel.
Full Professor, Technion-Israel Institute of Technology, Schulich Faculty of Chemistry, Israel.
Full Professor, Ben-Gurion University of the Negev, Department of Chemistry, Beer Sheva, Israel.
Associate Professor, Ben-Gurion University of the Negev, Department of Chemistry, Beer Sheva, Israel.
Senior Lecturer (Assistant Professor), Ben-Gurion University of the Negev, Department of Chemistry, Beer Sheva, Israel.
Senior Research Associate, The Scripps Research Institute, La Jolla, California, (with Professor Chi-Huey Wong).
Postdoctoral Associate, The Scripps Research Institute La Jolla, California, (with Professor Chi-Huey Wong).
Awards and Honors
The Israel Chemical Society Prize of Excellence 2019
The 2018 ERC advanced grant
Member of the Israel Young Academy.
The Michael Bruno Award in Bioorganic and Medical Chemistry.
The Henry Taub Prize for Academic Excellence.
The 11th Hirata Award
The Friedrich Bessel Research Award from the Alexander von Humboldt Foundation
Teva Award for Excellence in Memory of Eli Horovitz.
The Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry for 2013.
Ben-Gurion University -Toronto prize for excellence in research.
The 2011 Israel Chemical Society prize for Outstanding Young Chemist.
JSP Fellowship, the 46th Bürgenstock Conference, May 1-6, 2011 at Brunnen, Switzerland.
Dean’s Honors for Excellent Researcher (Faculty of Natural Sciences Ben-Gurion University).
Ma’of Fellowship: The fellowship covers the university salary for the first three years of my position as a Sr. Lecturer at Ben-Gurion University of the Negev, in addition to a research budget).
Postdoctoral Fellowship: Israel Science Foundation (ISF).
Eshkol Scholarship for Graduate Students: Israel Ministry of Science.
B.Sc. Dean’s Honors for Excellency (Ben-Gurion University).
Member of the International Advisory Board of Asian Journal of Organic Chemistry.
Member of the American Chemical Society (ACS).
Member of the Editorial Board of Organic and Biomolecular Chemistry.
Member of the American Peptide Society (APS).
Elected member of the executive board of the Israel Chemical Society.