Scientific Publications - Ashraf Brik : Ashraf Brik

157 Go to article

Dana Shkolnik#, Subhasis Dey#, Mahdi Hasan, Michael J. Matunis and Ashraf Brik* (# these authors contributed equally)

Chemical Protein Synthesis Combined with Protein Cell Delivery Reveals New Insights on the Maturation Process of SUMO2

Chemical Science, 2025, 16, 191- 198

156 Go to article

Abhishek Saha, Reem Mousa, Yam Alalouf, Pradeep Sadhu, Mahdi Hasan, ShaswatiMandal, Guy Mann, and Ashraf Brik*

Suspension Bead Loading (SBL): An Economical Protein Delivery Platform to Study URM1’s Behavior in Live Cells

Angewandte Chemie International Edition, 2024, 63, e202410135.

155 Go to article

Abhishek Saha, Laila A. Bishara, Yakop Saed, Ganga B. Vamisetti, Shaswati Mandal, Hiroaki Suga, Nabieh Ayoub*, and Ashraf Brik*

Exocyclic and Linker Editing of Lys63-linked Ubiquitin Chains Modulators Specifically Inhibits Non-homologous End-joining Repair

Angewandte Chemie International Edition, 2024, 63, e202409012.

154 Go to article

Mahdi Hasan, Deepanjan Panda, Guy Mann, Ashraf Brik*

De novo Semi-synthetic Platform for Monitoring Protein degradation in Live Cells

ChemBioChem, 2023, e202300731

153 Go to article

Betsegaw Lemma, Di Zhang, Ganga B. Vamisetti, Bryan G. Wentz, Hiroaki Suga, Ashraf Brik*, Jacek Lubkowski*, David Fushman*,

Mechanism of selective recognition of Lys48linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation

Nature Communications, 2023, 14,7212

152 Go to article

Yves Haufe, Veeresh Kuruva, Ziyana Samanani, Gonxhe Lokaj, Guy Kamnesky, Pranavkumar Shadarmarshan, Rezvan Shahoei, Dana Katz, Jared Sampson, Michael Pusch, Ashraf Brik*, Annette Nicke* and Abba Leffler*.

Basic residues at position 11 of α-conotoxin LvIA influence subtype selectivity between α3β2 and α3β4 nicotinic receptors via an electrostatic mechanism

ACS Chemical Neuroscience, 2023, 14, 24, 4311–4322

151 Go to article

Julia Kriegesmann , Ashraf Brik

Synthesis of ubiquitinated proteins for biochemical and functional analysis

Chemical Science, 2023, 14, 10025-10040

150 Go to article

Nikolaos Parisis, Pablo Dans Puigrὸs, Muhammad Jbara, Balveer Singh, Diane Schausi-Tiffoche, Diego Molina-Serrano, Isabelle Brun Heath, Denisa Hendrychova, Suman Kumar Maity, Diana Buitrago, Rafael Lema, Thiziri Nait Achour, Simona Giunta, Michael Girardot, Nicolas Talarek, Valérie Rofidal, Katerina Danezi, Damien Coudreuse, Marie-Noëlle Prioleau, Robert Feil, Modesto Orozco, Ashraf Brik, Pei-Yun Jenny Wu, Liliana Krasinska, Daniel Fisher*.

Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

Nature Communications, 2023, 14, 5104

149

Gal Halbi, Itay Fayer, Dina Aranovich, Shachar Gat, Mariela J. Pavan, Dikla Nachmias, Daniel Sevilla Sanchez, Ashraf Brik, Rony Granek and Anne Bernheim-Groswasser*

Smart-design of universally decorated nano-particles for drug delivery applications driven by active transport

The European Physical Journal E, 46, 74, 2023

148 Go to article

Yazid Mohamed Souf , Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert* and Sébastien Dutertre*

Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails

Marine Drugs, 2023, 21, 356

147 Go to article

Abhishek Saha, Hiroaki Suga, Ashraf Brik*

Combining Chemical Protein Synthesis and Random Non-standard Peptides Integrated Discovery for Modulating Biological Processes

Accounts of Chemical Research, 2023, 56, 14, 1953–1965

146 Go to article

Ganga B. Vamisetti# , Abhishek Saha# , Yichao J. Huang, Rajeshwer Vanjari, Guy Mann, Julia Gutbrod, Nabieh Ayoub, Hiroaki Suga* and Ashraf Brik* (# these authors contributed equally)

Selective Macrocyclic Peptide Modulators of Lys63-linked Ubiquitin Chains Disrupt DNA Damage Repair

Nature Communications, 2022, 13, 6174

145 Go to article

Shaswati Mandal and Ashraf Brik*

Proteins Through the Eyes of an Organic Chemist

Tetrahedron, 2022, 124, 133022 (Celebrating the 65th anniversary of the launch of Tetrahedron publications)

144 Go to article

Abhishek Saha, Shaswati Mandal, Jan Vincent V. Arafiles, Jacobo Gómez-González, Christian P. R. Hackenberger*, and Ashraf Brik*

Structure-Uptake Relationship Study of DABCYL-Derivatives Linked to Cyclic CPPs for Live-Cell Delivery of Synthetic Proteins

Angewandte Chemie International Edition, 2022, e2022075

143 Go to article

Guy Mann, Prasad Sulkshane, Pradeep Sadhu ,Tamar Ziv, Michael H. Glickman* and Ashraf Brik*

Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1

Molecules, 2022, 27, 4867

142 Go to article

Guy Mann, Pradeep Sadhu, and Ashraf Brik*

Synthetic Proteins behind the Plasma Barrier: Molecular Spies

Accounts of Chemical Research, 2022, 55, 15, 2055–2067

141 Go to article

Shaswati Mandal and Ashraf Brik*

Probing the Cell Delivery of Synthetic Diubiquitin Chains

Chemical Communications, 2022, 58, 8782-8785

140 Go to article

Rajeshwer Vanjari, Deepanjan Panda, Shaswati Mandal, Ganga B. Vamisetti, and Ashraf Brik*

Gold(I)-Mediated Rapid Cyclization of Propargylated Peptides via Imine Formation

Journal of American Chemical Society, 2022, 144, 11, 4966–4976

139 Go to article

Guy Mann, Pradeep Sadhu, Ashraf Brik*

Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of their Localization and Function in Live Cells

ChemBioChem, 2022, 23, e202200122

138 Go to article

Gilad Goldhirsh , Yelena Kravtsova-Ivantsiv, Gandhesiri Satish, Tamar Ziv, Ashraf Brik* and Aaron Ciechanover*

A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC

Proceeding National Academy of Science, USA, 2021, vol. 118 no.49, e2117254118

137 Go to article

Rajeshwer Vanjari#, Emad Eid#, Ganga B. Vamisetti, Shaswati Mandal, Ashraf Brik* (#These authors contributed equally)

A Highly Efficient Cyclization Approach of Propargylated Peptides via Gold(I)-Mediated Sequential C-N, C-O and C-C Bond Formation

ACS Central Science, 2021, 7, 12, 2021–2028

136 Go to article

Sara Gutkin , Satish Gandhesiri, Ashraf Brik*, Doron Shabat*

Synthesis and Evaluation of Ubiquitin-Dioxetane Conjugate as a Chemiluminescent Probe for Monitoring Deubiquitinase Activity

Bioconjugate Chemistry, 2020, 2021, 32, 10, 2141–2147

135 Go to article

Indrajit Sahu, Sachitanand M. Mali, Prasad Sulkshane, Cong Xu, Andrey Rozenberg, Roni Morag, Manisha Priyadarsini Sahoo, Sumeet K. Singh, Zhanyu Ding, Yifan Wang, Sharleen Day, Yao Cong, Oded Kleifeld*, Ashraf Brik*, Michael H. Glickman*

The 20S as a Stand-Alone Proteasome in Cells can Degrade the Ubiquitin-Tag

Nature Communications, 2021, 12:6173; Featured in Nature Communications Editors' Highlights

134 Go to article

Shay Laps#, Fatima Atamleh#, Guy Kamnesky, Shaked Uzi, Michael M. Meijler and Ashraf Brik* (#These authors contributed equally)

Insight on the Order of Regioselective Ultrafast Formation of Disulfide Bonds in (Antimicrobial) Peptides and Miniproteins

Angewandte Chemie International Edition, 2021,60, 24137–24143

133 Go to article

Guy Mann#, Gandhesiri Satish#, Prasad Sulkshane#, Shaswati Mandal, Michael H. Glickman* and Ashraf Brik* (# these authors contributed equally)

Synthesis and Delivery of a Stable Phosphorylated Ubiquitin Probe to Study Ubiquitin Conjugation in Mitophagy

Chemical Communications, 2021, 57, 9438 - 9441

132 Go to article

Gandhesiri Satish, Ganga B. Vamisetti, Ashraf Brik

Chemical Synthesis of Ubiquitinated Proteins for Biochemical Studies

(WILEY-VCH), 2021, 383-410, ISBN: 978-3-527-34660-8

131 Go to article

Ashraf Brik, Philip Dawson, Lei Liu

Total Chemical Synthesis of Proteins

(WILEY-VCH), 2021, ISBN: 978-3-527-34660-8

130 Go to article

Ganga B. Vamisetti, Roman Meledin, Mickal Nawatha, Hiroaki Suga and Ashraf Brik*

The Development of fluorescence-based competitive assay enabled the discovery of dimeric cyclicpeptide modulators of ubiquitin chains

Angewandte Chemie International Edition, 2021, 60, 45, 24137-24143, Hot Paper

129 Go to article

Shay Laps#, Gandhesiri Satish# and Ashraf Brik* (# These authors contributed equally)

Harnessing the Power of Transition Metals in Solid Phase Peptide Synthesis and Key Steps in (Semi)Synthesis of Proteins

Chemical Society Reviews, 2021, 50, 2367 - 2387

128 Go to article

Shaswati Mandal# , Guy Mann# , Gandhesiri Satish and Ashraf Brik* (# these authors contributed equally)

Enhanced Live-Cell Delivery of Synthetic Proteins Assisted by Cell-Penetrating Peptides Fused to DABCYL

Angewandte Chemie International Edition, 2021, 13, 60,7333 –7343 (Highlighted in Nature Chemistry, 2021, 13, 517–519).

127 Go to article

Joseph M. Rogers #, Mickal Nawatha #, Betsegaw Lemma , Ganga B. Vamisetti , Ido Livneh , Uri Barash , Israel Vlodavsky , Aaron Ciechanover , David Fushman , Hiroaki Suga* and Ashraf Brik* (# these authors contributed equally)

In vivo modulation of ubiquitin chains by N-methylated non- proteinogenic cyclic peptides

RSC Chemical Biology, 2021, 2, 513-522

126 Go to article

Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun and Ashraf Brik*

General Synthetic Strategy for Regioselective Ultrafast Formation of Disulfide Bonds in Peptides and Proteins

Nature Communications, 2021, 12:870

125 Go to article

Ganga B. Vamisetti#, Satish Gandhesiri# , Prasad Sulkshane, Guy Mann, Michael H. Glickman and Ashraf Brik* (# these authors contributed equally)

On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi) Synthesis of Challenging Proteins

Journal of American Chemical Society, 2020, 142, 19558−19569

124 Go to article

Muna Msallam, Hao Sun, Roman Meledin, Pauline Franz and Ashraf Brik*

Examining the role of phosphorylation of p19INK4d on its stability and ubiquitination using chemical protein synthesis

Chemical Science, 2020, 11, 5526 - 5531

123 Go to article

Muhammad Jbara#, Emad Eid# and Ashraf Brik* (# these authors contributed equally)

Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation

Journal of American Chemical Society, 2020, 142, 8203-8210

122 Go to article

Yichao Huang#, Mickal Nawatha#, Ido Livneh, Joseph M. Rogers, Hao Sun, Sumeet K. Singh, Aaron Ciechanover, Ashraf Brik* and Hiroaki Suga* (# these authors contributed equally)

Affinity Maturation of Macrocyclic Peptide Modulators of Lys48‐linked Diubiquitin by a Twofold Strategy

Chemistry - A European Journal, 2020, 26, 8022 –8027

121 Go to article

Emad Eid, Gabor Boross, Hao Sun, Muna Msallam, Sumeet Singh and Ashraf Brik*

Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions

Bioconjugate Chemistry, 2020, 31, 3, 889-894

120 Go to article

Muhammad Jbara, Suman Maity, Ashraf Brik*

Examining Several Strategies for the Chemical Synthesis of Phosphorylated Histone H3 Reveals the Effectiveness of the Convergent Approach

European Journal of Organic Chemistry, 2020, 21, 3128-3132 (selected as a very important paper)

119 Go to article

Hao Sun and Ashraf Brik*

The Journey for the Total Chemical Synthesis of a 53 kDa Protein

Accounts of Chemical Research, 2019, 52, 12, 3361-3371

118 Go to article

Guy Mann#, Gandhesiri Satish#, Roman Meledin#, Ganga B. Vamisetti and Ashraf Brik* (# these authors contributed equally)

Palladium Mediated Cleavage of Thiazolidine Backbone Modified Proteins in Live Cells

Angewandte Chemie International Edition ,2019, 58, 13540-13549

117 Go to article

Mickal Nawatha, Joseph Rogers, Steven M. Bonn, Ido Livneh, Betsegaw Lemma,Sachitanand M. Mali, Ganga B. Vamisetti, Hao Sun, Beatrice Bercovich, Yichao Huang, Aaron Ciechanover, David Fushman, Hiroaki Suga* and Ashraf Brik*

De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

Nature Chemistry, 2019, 11, 644–652

116 Go to article

Roman Meledin and Ashraf Brik

Mirroring Life’s Building Blocks

Cell Chemical Biology, 2019, 26, 5, 645 - 651

115 Go to article

Ashraf Brik, Ehud Keinan

Chemical Biology: Powerful Synergy Between Two Cultures

Israel Journal of Chemistry, 2019, 59, 3-6

114 Go to article

Shay Laps#, Hao Sun#, Guy Kamnesky, Ashraf Brik* (# these authors contributed equally)

Palladium Mediated Direct Disulfide Bond Formation in Proteins Containing S‐Acetamidomethyl‐Cysteine under Aqueous Conditions

Angewandte Chemie International Edition, 2019, 58, 5729-5733

113 Go to article

Michael Morgan, Muhammad Jbara, Ashraf Brik, Cynthia Wolberger*

Semi-synthesis of ubiquitinated histone H2B with a native or non-hydrolyzable linkage

Methods in Enzymology, 2019, 618, 1-27

112 Go to article

Hao Sun, Sachitanand Mali, Sumeet Singh, Roman Meledin, Ashraf Brik, Yong Tae Kwon, Yelena Kravtsova-Ivantsiv, Beatrice Bercovich, Aaron Ciechanover

Diverse Fate of Ubiquitin Chain Moieties: The Proximal is Degraded with the Target and the Distal Protects it from Removal and Recycles

Proceedings of the National Academy of Sciences, 2019, 116, 16, 7805-7812

111 Go to article

Melesse Nune, Michael T Morgan, Zaily Connell, Laura McCullough, Muhammad Jbara, Hao Sun, Ashraf Brik, Tim Formosa*, Cynthia Wolberger*

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

eLife, 2019, 8:e40988

110 Go to article

Ganga B. Vamisetti, Roman Meledin, Pushparathinam Gopinath and Ashraf Brik*

A Halogen Substitution in Isoquinoline Scaffold Switches the selectivity of Inhibition between USP2 and USP7

ChemBioChem, 2019, 20, 282-286

109 Go to article

Muhammad Jbara#, Shay Laps#, Michael Morgan, Guy Kamnesky, Guy Mann, Cynthia Wolberger, Ashraf Brik* (# these authors contributed equally)

Palladium Prompted On-Demand Cysteine Chemistry for the Synthesis of Challenging and Uniquely Modified Proteins

Nature Communications, 2018, 9:3154; Featured in Nature Communications Editors' Highlights

108 Go to article

Muhammad Jbara, Emad Eid and Ashraf Brik*

Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

Organic & Biomolecular Chemistry, 2018, 16, 4061-4064

107 Go to article

Roman Meledin, Sachitanand M. Mali, Oded Kleifeld* and Ashraf Brik*

Activity-Based Probes Developed by Applying a Sequential Dehydroalanine Strategy on Expressed Proteins Reveal a Potential α-globin Modulating Deubiquitinase

Angewante Chemie, 2018, International Edition, 57, 5645-5649

106 Go to article

Muhammad Jbara, Hao Sun, Guy Kamnesky and Ashraf Brik*

Chemical Chromatin Ubiquitylation

Current Opinions in Chemical Biology, 2018, 45:18–26.

105 Go to article

Hao Sun, Roman Meledin, Sachitanand M. Mali and Ashraf Brik*

Total Chemical Synthesis of Ester-Linked Ubiquitinated Proteins Unravels their Behavior with Deubiquitinases

Chemical Science, 2018, 9, 1661-1665

104 Go to article

Suman Kumar Maity, Muhammad Jbara, Guy Mann, Guy kamnesky and Ashraf Brik*

Total Chemical Synthesis of Histones and their Analogues Assisted by Native Chemical Ligation and Palladium Complexes

Nature Protocols, 2017, 12(11):2293-2322.

103 Go to article

Pushparathinam Gopinath, Atif Mahammed, Tal Eilon-Shaffer, Mickal Nawatha, Shimrit Ohayon, Doron Shabat*, Zeev Gross* and Ashraf Brik*

Switching Futile para-Quinone to Efficient ROS Generator: Ubiquitin Specific Protease-2 Inhibition, Electrocatalysis and Quantification

ChemBioChem, 2017, 18,1683 –1687, Highlighted in Cover Page

102 Go to article

Muhammad Jbara, Noga Guttmann-Raviv, Suman Kumar Maity, Nabieh Ayoub* and Ashraf Brik*

Total Chemical Synthesis of Methylated Analogues of Histone 3 Revealed KDM4D as a Potential Regulator of H3K79me3

Bioorganic and Medicinal Chemistry, 2017, 25(18):4966-4970.

101 Go to article

Muhammad Jbara, Suman kumar Maity, Ashraf Brik*

Palladium in the Chemical Synthesis and Modification of Proteins

Angewandte Chemie International Edition ,2017, International Edition, 56,10644 –10655.

100 Go to article

Somasekhar Bondalapati#, Emad Eid#, Sachitanand M. Mali, Cynthia Wolberger, Ashraf Brik* (# these authors contributed equally)

Total Chemical Synthesis of SUMO-2-Lys63-linked Diubiquitin Hybrid Chains Assisted by Removable Solubilizing Tags

Chemical Science, 2017, 8, 4027-4034.

99 Go to article

Sachitanand M. Mali, Sumeet K. Singh, Emad Eid, and Ashraf Brik*

Ubiquitin Signaling: Chemistry Comes to the Rescue

Journal of American Chemical Society, 2017, 139, 4971−4986. (Highlighted in Spotlights on Recent JACS Publications).

98 Go to article

Pushparathinam Gopinath and Ashraf Brik*

2,2′-Azobis[2-(2-imidazolin-2-yl)propane] Dihydrochloride

Encyclopedia of Reagents for Organic Synthesis 2016, DOI: 10.1002/047084289X.rn00922.pub2.

97 Go to article

Sumeet K. Singh#, Indrajit Sahu#, Sachitanand M. Mali, Hosahalli P. Hemantha, Oded Kleifeld, Michael H. Glickman*, and Ashraf Brik*

Synthetic uncleavable ubiquitinated proteins dissect proteasome deubiquitination and degradation and highlight distinctive fate of tetraubiquitin (# these authors contributed equally)

Journal of American Chemical Society, 2016, 138 (49), pp 16004–16015.

96 Go to article

Pushparathinam Gopinath#, Atif Mahammed#, Shimrit Ohayon, Zeev Gross* and Ashraf Brik* (# these authors contributed equally)

Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2

Chemical Science, 2016, 7, 7079-7086

95 Go to article

Muhammad Jbara, Shay Laps, Suman Kumar Maity and Ashraf Brik*

Palladium Assisted Cleavage of Peptides and Proteins Containing a Backbone Thiazolidine Linkage

Chemistry - A European Journal, 2016, 22, 14851 - 14855 (hot paper).

94 Go to article

Suman Kumar Maity#, Guy Mann#, Muhammad Jbara, Shay Laps, Guy Kamnesky, and Ashraf Brik* (# these authors contributed equally)

Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis

Organic Letters, 2016, 18, 3026–3029, ACS Editor Choice

93 Go to article

Roman Meledin, Sachitanand M. Mali, Sumeet Singh and Ashraf Brik*

Protein ubiquitination via Dehydroalanine: Development and Insights into the Diastereoselective 1,4-Addition Step

Organic & Biomolecular Chemistry, 2016, 14, 4817 - 4823

92 Go to article

Suman Kumar Maity#, Muhammad Jbara#, Shay Laps and Ashraf Brik* (# these authors contributed equally)

Efficient Palladium Assisted One-pot and Rapid Deprotection of Cysteine(Acetamidomethyl) Following Native Chemical Ligation and/or Desulfurization to Expedite Chemical Protein Synthesis

Angewandte Chemie International Edition ,2016, 55, 8108 - 8112

91 Go to article

Muhammad Jbara#, Suman Kumar Maity#, Mallikanti Seenaiah and Ashraf Brik* (# these authors contributed equally)

Palladium Mediated Rapid Deprotection of N-terminal Cysteine Under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins

Journal of American Chemical Society, 2016, 138 ,5069–5075.

90 Go to article

Pushparathinam Gopinath, Shimrit Ohayon, Mickal Nawatha and Ashraf Brik*

Chemical and Semisynthetic Approaches to Study and Target Deubiquitinases

Chemical Society Reviews, 2016, 45, 4171 - 4198

89 Go to article

Michael Morgan, Mahmood Haj-Yahya, Alison E. Ringel, Prasanthi Bandi, Ashraf Brik and Cynthia Wolberger*

Structural Basis for Histone H2B deubiquitination by SAGA DUB Module

Science, 2016, 351 725-728

88 Go to article

Somasekhar Bondalapati#, Muhammad Jbara# and Ashraf Brik* (# these authors contributed equally)

Expanding the Chemical Toolbox for the Synthesis of Large and Uniquely Modified Proteins

Nature Chemistry, 2016, 8, 407–418

87 Go to article

Muhammad Jbara, Suman Kumar Maity, Michael Morgan, Cynthia Wolberger* and Ashraf Brik*

Total Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module

Angewandte Chemie International Edition ,2016, 55, 4972-6.

86 Go to article

Suman Kumar Maity, Muhammad Jbara and Ashraf Brik

Chemical and Semisynthesis of Modified Histones

Journal of Peptide Science, 2016, 22: 252–259 (Festschrift for the journal on occasion of the 70th birthday of Stephen BH Kent) DOI: 10.1002/psc.2848

85 Go to article

Roman Meledin, Sachitanand M. Mali and Ashraf Brik*

Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains, Polyubiquitinated Peptides and Proteins

The Chemical Record, 2016, 16, 509–519

84 Go to article

Hosahalli P. Hemantha, Somasekhar Bondalapati, Sumeet Singh and Ashraf Brik*

Chemical synthesis of ubiquitin chains

Current Protocols in Chemical Biology, 2015, 7, 229-2448

83 Go to article

Shimrit Ohayon, Maya Refua and Ashraf Brik*

Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities

Organic and Biomolecular Chemistry, 2015,13, 8182-8186.

82 Go to article

Suman Kumar Maity, Shimrit Ohayon, and Ashraf Brik*

Synthesis of N-Hydroxy Isopeptide Containing Proteins

Organic Letters, 2015, 17 (14), pp 3438–3441

81 Go to article

Mallikanti Seenaiah, Muhammad Jbara, Sachitanand M. Mali and Ashraf Brik*

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

Angewandte Chemie International Edition, 2015, 54, 12374–12378

80 Go to article

Yelena Kravtsova-Ivantsiv, Inna Shomer, Victoria Cohen-Kaplan, Berend Snijder, Giulio Superti-Furga, Hedva Gonen, Thomas Sommer, Tamar Ziv, Arie Admon, Inna Naroditsky, Muhammad Jbara, Ashraf Brik, Eli Pikarsky, Yong Tae Kwon, Ilana Doweck, Aaron Ciechanover*

KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth

Cell, 2015, 161, 2, p333–347

79 Go to article

Somasekhar Bondalapati, Wissam Mansour, Mark A. Nakasone, Suman Kumar Maity, Michael H. Glickman* and Ashraf Brik*

Chemical Synthesis of Phosphorylated Ubiquitin and Diubiquitin Exposes Positional Sensitivities of E1-E2 Enzymes and Deubiquitinases

Chemistry - A European Journal, Volume 21, Issue 20, May 11, 2015, 7360–7364.

78 Go to article

Shimrit Ohayon, Maya Refua, Adi Hendler, Amir Aharoni, and Ashraf Brik

Harnessing the Oxidation Susceptibility of Deubiquitinases for Inhibition with Small Molecules

Angewandte Chemie International Edition, 2015, 54, 599-603

77 Go to article

Ashraf Brik

Author Profile

Angewandte Chemie International Edition, 2014, 53, 1738

76 Go to article

Muhammad Jbara, Mallikanti Seenaiah and Ashraf Brik*

Solid Phase Chemical Ligation Employing a Rink Amide Linker for the Synthesis of Histone H2B Protein

ChemComm, 2014, 50, 12534-7.

75 Go to article

Somasekhar Bondalapati, Emil Ruvinov, Olga Kryukov, Smadar Cohen* and Ashraf Brik*

Rapid End-Group Modification of Polysaccharides for Biomaterial Applications in Regenerative Medicine

Macromolecular Rapid Communications 2014, 35, 20, 1754-1762.

74 Go to article

Daria Krutauz, Noa Reis, Mark A Nakasone, Peter Siman, Daoning Zhang, Donald S Kirkpatrick , Steven P Gygi, Ashraf Brik, David Fushman, Michael H Glickman

Extended ubiquitin species are protein-based DUB inhibitors

Nature Chemical Biology, 2014, 10(8), 664-U212.

73 Go to article

Lindsey Long, Joseph P Thelen, Melonnie Furgason, Mahmood Haj-Yahya, Ashraf Brik, Dongmei Cheng, Junmin Peng, and Tingting Yao*

The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination

Journal of Biological Chemistry, 2014, 289(13), 8916-30.

72 Go to article

Hosahalli P. Hemantha, Sudhir N. Bavikar, Yifat Herman-Bachinsky, Najat Haj-Yahya, Somasekhar Bondalapati, Aaron Ciechanover, Ashraf Brik*

Non-Enzymatic Polyubiquitination od Expressed proteins

Journal of the American Chemical Society 2014, 136 (6),2665–2673. Highlighted 1) ACS Editor Choice; 2) Spotlights on Recent JACS Publications 3) ACS Chemical Biology.

71 Go to article

Christian F.W. Becker, Ashraf Brik, Phil Dawson and Christian P. R. Hackenberger

Chemical protein synthesis

Journal of Peptide Science 2014, 20, 2, 63.

70 Go to article

Najat-Haj Yahya, Roman Meledin, Hosahalli P. Hemantha, Somasekhar Bondalapati, Mallikanti Seenu, Ashraf Brik*

Dehydroalanine-Based Diubiquitin Activity Probes

Organic Letters, 2014, 16, 540–543.

69 Go to article

Mahmood Haj-Yahya, Bruno Fauvet, Yifat Herman-Bachinsky, Mirva Hejjaoui, Sudhir N. Bavikar, Subramanian Vedhanarayanan Karthikeyan, Aaron Ciechanover*, Hilal A. Lashuel*, Ashraf Brik*

Synthesis of tetra-ubiquitinated α-Synuclein reveals novel insights into the roles of ubiquitin chain in regulating pathophysiology

Proceeding National Academy of Science. USA, 2013, vol. 110 no.44, 17726–17731. Highlighted in 1) a commentary by Ivan Dikic et al in PNAS (Breaking the limits of artifical ubiquitination),PNAS, 2013, vol. 110 no.44, 17606–17607.2)News of the Week of C&EN. Issue: Vol. 91, #38, Sept. 23, 2013

68 Go to article

Najat Haj-Yahya, Mahmood Haj-Yahya, Carlos A. Castañeda, Liat Spasser, Hosahalli P. Hemantha, Muhammad Jbara, Marlin Penner, Aaron Ciechanover,David Fushman and Ashraf Brik*

Modifying the Vicinity of the Isopeptide Bond to Reveal Differential Behavior of Ubiquitin Chains with Interacting Proteins: Organic Chemistry Applied to Synthetic Proteins

Angewandte Chemie International Edition 2013, 52, 11149 –11153

67 Go to article

Bruno Fauvet, Sara M. Butterfield, Jonas Fuks, Ashraf Brik, Hilal A. Lashuel*

One-pot total chemical synthesis of human alpha-synuclein

Chemical Communications, 2013,49,9254

66 Go to article

Efrat Shema-Yaacoby, Miroslav Nikolov, Mahmood Haj-Yahya, Peter Siman, Eric Allemand, Yuki Yamaguchi, Christian Muchardt, Henning Urlaub, Ashraf Brik, Moshe Oren*

Wolfgang Fischle*: Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of the SWI/SNF complex to regulate transcription

Cell Reports, 2013, 4, 601-608

65 Go to article

Peter Siman#, Subramanian Vedhanarayanan Karthikeyan#, Miroslav Nikolov, Wolfgang Fischle and Ashraf Brik* (# these authors contributed equally).

Convergent Chemical Synthesis of Histone H2B Protein Enabled Site Specific Ubiquitination at Lys34

Angewandte Chemie International Edition 2013,52, 8059-8063. Selected by the editors as a Hot Paper

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Ashraf Brik*

Chemistry and biology of peptides, proteins and beyond

Bioorganic and Medicinal Chemistry, 2013, 21, 3398-3399; (Editorial, Special BMC issue in honor of the 2013 Tetrahedron Young Investigator Award winner Professor Ashraf Brik).

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Tal Moyal, Hosahalli Hemantha, Peter Siman, Maya Refua, Ashraf Brik*

Highly Efficient One-Pot Ligation and Desulfurization

Chemical Science, 2013, 4(6), 2496-2501.

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Hosahalli Hemantha and Ashraf Brik*

Non-Enzymatic Synthesis of Ubiquitin Chains: Where Chemistry Makes a Difference

Bioorganic and Medicinal Chemistry, 2013, 21, 3411-3420; (Special BMC issue in honor of the 2013 Tetrahedron Young Investigator Award winner Professor Ashraf Brik).

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Roman Meledin, Ashraf Brik,* Amir Aharoni,*

Dissecting the Roles of the N- and C-flanking Residues of Acetyl-lysine Substrate for SIRT1 activity

ChemBioChem, 2013, 14, 577–581.

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Mahmood Haj-Yahya, Najat Eltrteer, Shimirit Ohayon, Efrat Shema, Eran Kotler, Moshe Oren and Ashraf Brik*

N-methylation of Isopeptide Bond as a Strategy to Resist Deubiquitinases

Angewandte Chemie International Edition 2012, 51(46), 11535-9.

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Tal Moyal, Sudhir Bavikar, Subramanian Vedhanarayanan Karthikeyan, Hosahalli Hemantha, Ashraf Brik*

Polymerization Behavior of a Bifunctional Ubiquitin Monomer as a Function of the Nucleophile Site and Folding Conditions

Journal of the American Chemical Society, 2012, 134(38),16085-16092

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Liat Spasser, Ashraf Brik*

Chemistry and Biology of the Ubiquitin Signal (Invited Review)

Angewandte Chemie International Edition 2012, 51, 6840-6862.

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Nitzan Shabek, Yifat Herman-Bachinsky, Samuel Buchsbaum, Oded Lewinson, Mahmood Haj-Yahya, Mirva Hejjaoui, Hilal A. Lashuel,Thomas Sommer, Ashraf Brik, and Aaron Ciechanover*

The Size of the Proteasomal Substrate Determines whether its Degradation will be Mediated by Mono- or Polyubiquitylation

Molecular Cell, 2012, 48, 1-11. Highlighted in Nature Reviews Molecular Cell Biology 13, 602 (October 2012) DOI: 10.1038/nrm3445

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Peter Siman, Subramanian Vedhanarayanan Karthikeyan and Ashraf Brik*

Native Chemical Ligation at Glutamine

Organic Letters, 2012, 14, 1520-1523. Highlighted in the Peptides virtual issue that compiles the most noteworthy recent research in the field that were published in Org Lett, JOC and JACS; September 7, 2012, Volume 1, Issue 2

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Gilad Fuchs, Efrat Shema, Rita Vesterman, Eran Kotler, Zohar Lifshits, Sylvia Wilder, Lior Golomb, Ariel Pribluda, Feng Zhang, Mahmood Haj-Yahya, Ester Feldmesser, Ashraf Brik, Xiaochun Yu, Jacob Hanna, Daniel Aberdam, Eytan Domany and Moshe Oren*

RNF20 and USP44 regulate embryonic stem cell differentiation by modulating H2B monoubiquitylation

Molecular Cell, 2012, 46, 662-673.

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Peter Siman, Ashraf Brik*

Chemical and Semisynthesis of Posttranslationally Modified Proteins

Organic & Biomolecular Chemistry, 2012, 10, 5684-5697

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Shimrit Ohayon, Liat Spasser, Amir Aharoni*, Ashraf Brik*

Targeting Deubiquitinases Enabled by Chemical Synthesis of Proteins

Journal of the American Chemical Society, 2012, 134, 3281-3289.

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Sudhir N. Bavikar, Liat Spasser, Mahmood Haj-Yahya, Subramanian Vedhanarayanan Karthikeyan, Tal Moyal, K. S. Ajish Kumar and Ashraf Brik*

Chemical Synthesis of Ubiquitinated Peptides with Varying Lengths and Types of Ubiquitin Chains to Explore the Activity of Deubiquitinases

Angewandte Chemie International Edition 2012,51, 758–763.

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Ashraf Brik, Philip E. Dawson, Stephen BH Kent

Guest Editorial: Chemical Protein Synthesis

Israel Journal of Chemistry, 2011, 51, 852-853

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Ashraf Brik*

Fighting Hepatitis C Virus with Peptide Nanotubes

Chemistry and Biology, 2011, 18, 1347-1348. (Invited Commentary)

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K. S. Ajish Kumar, Ashraf Brik*

δ-Mercaptolysine Assisted Ubiquitination

Israel Journal of Chemistry, 2011, 51, 900-907. (Special Issue on Protein Synthesis, Edited by Ashraf Brik, Philip E. Dawson, Stephen BH Kent)

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Carlos A. Castañeda, Liat Spasser, Sudhir N. Bavikar, Ashraf Brik*, David Fushman*

Segmental Isotopic Labelling of Ubiquitin Chains to Unravel Monomer-Specific Molecular Behavior

Angewandte Chemie International Edition 2011, 50, 11210–11214

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Natalie Zeytuni, Ertan Ozyamak, Kfir Ben-Harush, Geula Davidov, Maxim Levin, Yair Gat, Tal Moyal, Ashraf Brik, Arash Komeili, Raz Zarivach*

Self-Recognition Mechanism of MamA, a Magnetosome-Associated TPR-Containing Protein, Promotes Complex Assembly

Proceedings of the National Academy of Science, USA, 2011, 108, E480-E487

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K. S. Ajish Kumar#, Sudhir N. Bavikar#, Liat Spasser, Shimrit Ohayon, Tal Moyal and Ashraf Brik* (# these authors contributed equally)

Total Synthesis of a 304 residue, K48-Linked Tetraubiquitin

Angewandte Chemie International Edition, 2011,50, 6137-6141;. Selected by the editors as a Hot Paper. See highlight on this paper in News of the Week of C&EN, May 30, 2011, Volume 89, number 22, p. 7

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Rinat Roytman, Lihi Adler-Abramovich, K. S. Ajish Kumar, Ting-Chun Kuan, Chun-Cheng Lin, Ehud Gazit*, Ashraf Brik*

xploring the Self-Assembly of Glycopeptides Using Diphenylalanine Scaffold

Organic & Biomolecular Chemistry, 2011, 9, 5755-5761

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Peter Siman, Ofrah Blatt, Tal Moyal, Tsafi Danieli, Mario Lebendiker, Hilal A. Lashuel, Assaf Friedler*, Ashraf Brik*

Chemical Synthesis and Expression of the HIV-1 Rev Protein

ChemBioChem, 2011, 12, 1097-1104

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K. S. Ajish Kumar, Liat Spasser, Shimrit Ohayon, Lesly Erlich, Ashraf Brik*

Expeditious Chemical Synthesis of Ubiquitinated Peptides Employing Orthogonal Protection, Native Chemical Ligation

Bioconjugate Chemistry (ACS publication), 2011, 22, 137-143.

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Mirva Hejjaoui#, Mahmood Haj-Yahya#, K. S. Ajish Kumar, Ashraf Brik*, Hilal A. Lashuel* (# these authors contributed equally)

Towards elucidating the role of ubiquitination in the pathogenesis of Parkinson’s disease using semisynthetic ubiquitinated α-synuclein

Angewandte Chemie International Edition 2011, 50, 405.

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Liat Spasser, K. S. Ajish Kumar, Ashraf Brik*

Side-Chain Assisted Ligation: Scope and limitation

Journal of Peptide Science, 2011, 17, 252-255.

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K. S. Ajish Kumar#, Liat Spasser#, Lesly A. Erlich, Sudhir N. Bavikar, Ashraf Brik* (# these authors contributed equally)

Total Chemical Synthesis of all di-Ubiqutin Chains, Angewandte Chemie Int. Ed. 2010,49, 9126-9131

This communication has been selected as a frontispiece for Angewandte Chemie International Edition. See highlights about this paper: 1) C&EN, Vol 88 # 41, October 11, 2010; 2) Carpe Diubiquitin, by L. Martin & R. T. Raines, Angewandte Chemie Int. Ed. 2010,49, 9042-9044;3) C&EN, December 20, 2010, issue: Chemical Year in Review 2010

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Ziv Harpaz, Peter Siman, K. S. Ajish Kumar, Ashraf Brik*

Protein Synthesis Assisted by Native Chemical Ligation at Leucine

ChemBioChem, 2010, 11, 1232-1235

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K. S. Ajish Kumar, Ashraf Brik*

Accessing Posttranslationally Modified Proteins through Thiol Positioning

Journal of Peptide Science, 2010, 16, 524-529

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Mahmood Haj-Yahya, K. S. Ajish Kumar, Lesly A Erlich, Ashraf Brik*

Protecting Group Variations of δ-Mercaptolysine Useful in Chemical Ubiquitylation

Peptide Science, 2010, 94, 504-510.

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Ashraf Brik*

New Strategies for Glycopeptides, Neoglycopeptides and Glycoproteins Synthesis, In Comprehensive Natural Products II Chemistry and Biology

Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford, 2010; volume 6, pp.55–89.

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esly A. Erlich, K. S. Ajish Kumar, Mahmood Haj-Yahya, Philip E. Dawson, Ashraf Brik*

N-Methylcysteine-Mediated Total Chemical Synthesis of Ubiquitin Thioester

Organic & Biomolecular Chemistry, 2010, 8, 2392-2396

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K. S Ajish Kumar, Mahmood Haj-Yahya, Diana Olschewski, Hilal A. Lashuel, Ashraf Brik*

Highly Efficient and Chemoselective Peptide Ubiquitylation

Angewandte Chemie International Edition, 2009, 48, 8090-8094; See highlight on this paper in C&EN, November 16, 2009, Volume 87.

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K. S. Ajish Kumar, Ziv Harpaz, Mahmood Haj-Yahya, Ashraf Brik*

Side-Chain Assisted Ligation in Protein Synthesis

Bioorganic & Medicinal Chemistry Letters, 2009, 19, 3870–3874.

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Natalia Nepomniaschiy, Valerie Grimminger, Aviv Cohen, Saviana DiGiovanni, Hilal Lashuel* Ashraf Brik*

Switch Peptide via Staudinger Reaction

Organic Letters, 2008, 11, 5243-5246.

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Ashraf Brik*

Metathesis in Peptides and Peptidomimetics

Advanced Synthesis and Catalysis, 2008, 350, 1661-1675.

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Marina-Yamit Lutsky, Natalia Nepomniaschiy, Ashraf Brik*

Peptide Ligation via Side-Chain Auxiliary

Chemical Communications, 2008, 10, 1229-1231.

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Michael J. Giffin, Holly Heaslet, Ashraf Brik, Ying-Chuan Lin, Gabrielle Cauvi1, Chi-Huey Wong, Duncan E. McRee, John H. Elder, C. David Stout, Bruce E. Torbett

AB2, an Azide-Alkyne Click Compound, is a Potent Protease Inhibitor of Multidrug-Resistant HIV-1

Journal of Medicinal Chemistry, 2008, 51, 6263-6267.

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Clay S. Bennett, Richard J. Payne, Simon Ficht, Stephen M. Dean, Ashraf Brik, Chi-Huey Wong

Sugar-Assisted Glycopeptide Ligation with Complex Oligosaccharides

Journal of The American Chemical Society, 2008, 130, 11945-11952

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Richard J. Payne, Simon Ficht, Sishi Tang, Ashraf Brik, Yu-Ying Yang, David A. Case, Chi-Huey Wong

Extended Sugar-Assisted Glycopeptide Ligations

Development, Scope and Applications” Journal of The American Chemical Society, 2007, 129, 13527-13536

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Yu-Ying, Yang, Simon Ficht, Ashraf Brik*, Chi-Huey Wong*

Sugar-Assisted Ligation in Glycoprotein Synthesis

Journal of the American Chemical Society, 2007, 129, 7690-7701.

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Ashraf Brik*, Chi-Huey Wong*

Sugar-Assisted Ligation for the Synthesis of Glycopeptides

Chemistry-A European Journal, 2007, 13, 5670-5675.

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Ashraf Brik*, Chi-Huey Wong*

Sugar-Assisted Ligation for the Synthesis of Glycopeptides

Chemistry – A European Journal Volume 13, Issue 20 p. 5670-5675

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Ashraf Brik,* Simon Ficht, Yu-Ying Yang, Chi-Huey Wong*

Sugar Assisted ligation for the Synthesis of N-linked Glycopeptide with Broad Sequence Tolerance at the Ligation Junction

Journal of the American Chemical Society, 2006, 128, 15026-15033. See highlight about this paper in News & Views, Nature, 2007, 445, 31-33.

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Ashraf Brik, Simon Ficht, Chi-Huey Wong

Strategies for the Preparation of Homogenous Glycoproteins,

Current Opinion in Chemical Biology, 2006, 10, 1-7.

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Ying-Chuan Lin, Ashraf Brik, Aymeric de Parseval, Karen Tam, Bruce Torbett, Chi-Huey Wong, John H. Elder

Altered Gag-Pol Polyprotein Cleavage Specificity of FIV/HIV Mutant Proteases as Demonstrated in Cell-Based Expression System

Journal of Virology, 2006, 80, 7832-7843.

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Ashraf Brik, Yu-Ying Yang, Simon Ficht, Chi-Huey Wong

Sugar Assisted Glycopeptide Ligation

Journal of The American Chemical Society, 2006, 128, 5626-5627.

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Ashraf Brik, Chung-Yi Wu and Chi-Huey Wong

Microtiter Plate Based Chemistry and In Situ Screening: A Useful Approach for Rapid Inhibitors Discovery

Organic & Biomolecular Chemistry, 2006, 4, 1446-1457.

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Fu-Sen Liang, Ashraf Brik, Ying-Chuan Lin, John H. Elder, and Chi-Huey Wonע

Epoxide Opening in Water for Rapid Inhibitor Discovery in Microtiter Plate and In situ screening

Bioorganic & Medicinal Chemistry, 2006, 14, 1058-1062

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Chung-Yi Wu, Ashraf Brik, Sheng-Kai Wang, Yu-Hsien Chen, and Chi-Huey Wong

Tetrabutylammonium Fluoride-Mediated Rapid Alkylation Reaction in Microtiter Plates for Discovery of Enzyme Inhibitors In situ

ChemBiochem, 2005, 6, 2176-2180.

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Ashraf Brik, Jerry Alexandratos, Ying-Chuan Lin, John H. Elder, Arthur J. Olson, David S. Goodsell, Alexander Wlodawer and Chi-Huey Wong

1,2,3 Triazole as a Peptide Bond Surrogate in the Rapid Synthesis of HIV Protease Inhibitors

ChemBiochem, 2005, 6, 1167-1169 (highlighted on the cover page)

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Ashraf Brik, Chung-Yi Wu, Michael D. Best and Chi-Huey Wong: Tetrabutylammonium Fluride-Assisted Rapid N9-Alkylation on Purine Ring

Application to Combinatorial reaction in Microtiter plates for the Discovery of Potent Sulfotransferase Inhibitors In situ

Bioorganic & Medicinal Chemistry, 2005, 13, 4622-4626.

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Ashraf Brik and Ehud Keinan

Catalytic Antibodies in Natural Product Synthesis

Ehud Keinan, ed. (WILEY-VCH), 2005, 132-152

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Chung-Yi Wu, Jia-Tsrong Jan, Shiou-Hwa Ma, Chih-Jung Kuo, Hsueh-Fen Juan, Yih-Shyun E Cheng, Hsuan Cheng Huang, Douglass Wu, Ashraf Brik, Fu-Sen Liang, Rai-Shung Liu, Jim-Min Fang, Shui-Tein Chen Po-Huang Liang,Chi-Huey Wong

Small Molecules Targeting Severe Acute Respiratory Syndrome (SARS) Human Coronavirus

Proceedings of the National Academy of Science, USA, 2004, 101(27), 10012-10017.

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Norman Metanis, Ashraf Brik, Ehud Keinan, and Philip E. Dawson

Electrostatic interaction dominate the contribution of Arg39 in 44 Oxalocrotonate Tautomerase

Journal of the American Chemical Society, 2004, 126 (40), 12726-12727.

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Ting-Jen Chen, Ashraf Brik, Chi-Huey Wong and Chen-Chen Kan

A model System for High-Throughput Screening of Novel Human Immunodeficiency Virus (HIV) Protease Inhibitors in Escherichia Coli

Antimicrobial Agents and Chemotherapy, 2004, 48(7), 2437-2447.

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Michael D. Best, Ashraf Brik, Lac V-Lee, Ali Chapman, Wei-Chieh Cheng and Chi-Huey Wong

Rapid Discovery of Potent Sulfotransferase Inhibitors by Diversity-Oriented Reaction in Microplates Followed by in Situ Screening

ChemBioChem, 2004, 5, 811-819.

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Ashraf Brik, John Muldoon, Ying-Chuan Lin, John H. Elder, David S. Goodsell, Arthur J. Olson, Valery V. Fokin, K. Barry Sharpless and Chi-Huey Wong

A Rapid Diversity-Oriented Synthesis and In Situ Screening of HIV Protease Inhibitors

ChemBioChem, 2003, 4, 1246-1248.

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Chi Ching Mak, Ashraf Brik, Danica L. Lerner, John H. Elder, Garrett M. Morris, Arthur J. Olson,Chi-Huey Wong

Design and Synthesis of Broad-Based Mono- and Bi-cyclic Inhibitors of FIV and HIV Proteases

Bioorganic & Medicinal Chemistry, 2003, 11, 2025-2040

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Ashraf Brik and Chi-Huey Wong: HIV Protease

Mechanism and Drug Discovery

Organic & Biomolecular Chemistry, 2003, 1, 5-14 (highlighted on the cover page),(Top 10 most downloaded OBC articles in 2006-2007 and 2009).

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Ashraf Brik, Ying-Chuan Lin, John Elder, Chi-Huey Wong

A Quick Diversity-Oriented Amide-Forming Reaction to Optimize p-subsite Residues of HIV Protease Inhibitors

Chemistry & Biology, 2002, 9, 891-896

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Ashraf Brik, Lawrence J. D’Souza, Ehud Keinan, Flavio Grynszpan and Philip E. Dawson

Mutants of 4-Oxalocrotonate Tautomerase Catalyze the Decarboxylation of Oxaloacetate Through an Imine Mechanism

ChemBioChem, 2002, 3, 845-851, (highlighted on the cover page).

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Ashraf Brik, Philip E. Dawson and Ehud Keinan

The Product of the Natural Reaction Catalyzed by 4-oxalocrotonate Tautomerase Becomes an Affinity Label of its Mutant

Bioorganic & Medicinal Chemistry, 2002,10, 3891-3897.

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Ashraf Brik, Ehud Keinan, and Philip E. Dawson

Protein Synthesis by Solid-Phase Chemical Ligation Using a Safety Catch Linker

Journal of Organic Chemistry, 2000, 65, 3829-3835

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Nizar Haddad, Michael Grishko, and Ashraf Brik

Studies Towards Total Synthesis of Borrelidin, Stereoselective Synthesis of the Polysubstituted Macrolidic Part

Tetrahedron Letters, 1997, 38, 6075-6078

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Nizar Haddad, Ashraf Brik, and Michael Grishko

Studies Towards Total Synthesis of Borrelidin, Regioselective Methylation of Bis-epoxides and Structure Determination

Tetrahedron Letters 1997, 38, 6079-6082.